Tris(Hydroxymethyl)Aminomethane CAS 77-86-1
Tris(Hydroxymethyl)Aminomethane CAS 77-86-1 With Best Quality
- Appearance:Powder
- Purity:99.8%
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Name: Tris(Hydroxymethyl)Aminomethane
CAS: 77-86-1
MOQ: 1KG
Directory Guidance on Tris(Hydroxymethyl)Aminomethane
Chemical Structure
Basic Info:
| Melting point | 167-172 °C(lit.) |
| Boiling point | 219-220 °C10 mm Hg(lit.) |
| density | 1,353 g/cm3 |
| vapor pressure | 0.0267 hPa (20 °C) |
| refractive index | 1.4170 (estimate) |
| Fp | 219-220°C/10mm |
Product Introduction:
Tris(Hydroxymethyl)Aminomethane (Tris), chemical form C₄H₁₁NO₃ CAS number 77-86-1, is a white crystalline or powdered organic compound named for the presence of an amino group and three hydroxymethyl groups in its molecule. It is easily soluble in water and ethanol at room temperature, slightly soluble in organic solvents such as ethyl acetate and benzene, but insoluble in ether and carbon tetrachloride. The melting point of Tris is 168-172℃, the boiling point is about 219-220℃ (10 mmHg), its aqueous solution is weakly alkaline, the pKa value is 8.1 at 25℃, and the effective buffer range is pH 7.0-9.2, which makes it an indispensable buffer in biochemical experiments.
From a chemical structure perspective, the amino and hydroxymethyl groups of Tris (Hydroxymethyl) Amine endow it with unique reactivity. Amino groups can be condensed with aldehydes, and hydroxymethyl groups provide hydrophilic and intermolecular hydrogen bond formation, enabling them to stabilize the structure of biological macromolecules such as proteins and nucleic acids in aqueous solutions. In addition, Tris is slightly corrosive to metal materials (such as copper, aluminum) and may decompose under high temperature or strong oxidation conditions, so it is necessary to pay attention to environmental conditions when storing and using.
The industrial method for the preparation of Tris(Hydroxymethyl)Aminomethane is usually based on trihydroxymethyl methane as raw material, and is completed by methanol solution dissolution, activated carbon decolorization, concentration and crystallization under reduced pressure, etc. For example, the industrial-grade raw materials and methanol aqueous solution (volume ratio 2:3) are mixed and heated to 60 ° C after dissolution, activated carbon is added to decolorize and filter, and then reduced pressure at 80 ° C, concentrated and crystallized, and finally washed and dried with anhydrous ethanol, the purity can reach more than 99.5%. This process is not only efficient, and the solvent can be recycled, in line with the concept of green chemistry.
In terms of safety, although Tris(Hydroxymethyl)Aminomethane is a low toxic substance (rat LD₅₀ 5900 mg/kg), it is necessary to avoid inhalation of dust or direct contact with skin and eyes. Its dust may cause respiratory irritation, and the solution may be corrosive to mucous membranes at high concentrations. Therefore, laboratory and industrial production need to be equipped with protective equipment, and operate under ventilated conditions.
Nature and Specifications:
| Item | Specification |
| Product Name | Tris(Hydroxymethyl)Aminomethane |
| CAS No. | 77-86-1 |
| Appearance | Powder |
| Shelf Life | 2 years |
| Packing | As your requirements |
| storage temp. | 20-25°C |
| solubility | H2O: 4 M at 20 °C, clear, colorless |
| form | crystalline |
| color | white |
| PH | 10.5-12.0(4 m in water, 25 °C) |
| PH Range | 7 – 9 |
Product service:
- Certificate Of Analysis (COA)
- Material Safety Data Sheet (MSDS)
- Route of synthesis (ROS)
- Method of Aanlysis (MOA)
- Nuclear Magnetic Resonance (NMR)
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- Factory audit
The core value of Tris(Hydroxymethyl)Aminomethane in the biomedical field is as a buffer. For example, genetic engineering applications use a combination of Tris-HCl buffer (pH 7.4-8.0) to maintain stable conditions during DNA extraction and electrophoresis experiments, where a stable pH environment plays an integral role in preventing nucleic acid degradation. In addition, TE buffer (pH 8.0), a combination of Tris and EDTA, is considered an aprotic solvent for long-term DNA storage; TAE (Tris-acetic acid-EDTA) and TBE (Tris-boric acid-EDTA) buffers are universal media for nucleic acid electrophoresis applications. Buffers derived from Tris can also be used in protein work, where they are used as enzyme activity maintenance systems, and as protein crystallization solvents, where ionic strength modulation is used as a crystal growth promoter.
In clinical medicine, the secondary applications of Tris(Hydroxymethyl)Aminomethane are more prominent. Tris(Hydroxymethyl)Aminomethane has also become widely used in the industry. On the one hand, it is a key intermediate in the production of surfactants, vulcanization accelerators and epoxy resin curing agents, which greatly improves the efficiency of chemical manufacturing. The hydroxymethyl group can react with fatty acids to generate non-ionic surfactant components, which are mainly used in detergent and emulsifier formulations. It can also be used as a crosslinker in the coatings and inks industry to enhance the dispersibility and adhesion of water-based coatings, while controlling the pH value, thereby reducing the emission of volatile organic compounds (VOCs) and complying with environmental regulations. This will make it possible to synthesize indoor formaldehyde adsorbent materials by using its exothermic reaction with formaldehyde to purify indoor air.
In the field of daily chemicals and personal care, Tris(Hydroxymethyl)Aminomethane is a widely used ingredient in high-end skin care products and shampoos because of its weak alkalinity and moisturizing properties. For example, Tris can stabilize the pH value of hyaluronic acid serum so that the active ingredients will not be inactivated; it is used as a buffer in hair dyes to reduce hair dye damage. Due to its low toxicity and good biocompatibility, this compound is also used as a pharmaceutical grade excipient for pH-adjusting eye drops and injections.
In the field of emerging technologies, Tris(Hydroxymethyl)Aminomethane is widely used. In particular, biosensors, since Tris provides a fixed medium, the stability of enzymes or antibodies is higher; in addition, the synthesis of nanomaterials can be manipulated by guiding the growth of metal nanoparticles through the amino groups of Tris and controlling their morphology and size by means of it. Furthermore, environmental protection is possible by using Tris to prepare activated carbons that can adsorb heavy metal ions and organic pollutants, which can be used in wastewater treatment and air purification.
The core competitiveness of Tris(Hydroxymethyl)Aminomethane comes from its unique combination of chemical properties. First, its wide buffer range (pH 7.0-9.2) covers the physiological environment requirements of most biological systems, and its buffer capacity is high (the pH change of 0.1 M solution is less than 0.1 unit/ten-fold dilution), which is significantly better than phosphate and carbonate buffer systems. Secondly, Tris has a stable molecular structure and can be stored for a long time under dry conditions without hygroscopic decomposition. The shelf life of the solution at 4°C can reach several years, which greatly reduces the storage cost. In addition, the characteristic of its aqueous solution that does not absorb CO₂ avoids the interference of carbonate precipitation, which is particularly suitable for experiments that require precise control of ionic strength.
From the production point of view, the preparation process of Tris(Hydroxymethyl)Aminomethane is mature and environmentally friendly. The purity of industrial grade products can reach more than 99%, while the purity of pharmaceutical grade (ChP, EP, USP standards) is more than 99.5%, and the heavy metal residue is less than 5 ppm, fully meeting the GMP requirements. The methanol recycling technology used in the production process reduces the discharge of waste liquid, and the activated carbon decolorization step ensures that the product is colorless and transparent, which is suitable for optical sensitive experiments.
In terms of economy, Tris(Hydroxymethyl)Aminomethane has significant cost advantages. As a bulk chemical, its global annual production capacity exceeds 100,000 tons, and large-scale production makes the raw material cost lower than similar buffers (such as HEPES). For example, the price of 500g lab-grade Tris is about 128 yuan, and the price of industrial grade tons can be controlled within 20,000 yuan, which is far more cost-effective than special buffer reagents. In addition, its versatility reduces the trouble of users needing to purchase a variety of reagents, further reducing the cost of comprehensive use.
In the dimension of safety and compliance, the safety data of Tris(Hydroxymethyl)Aminomethane is complete and has been certified by REACH, FDA and other multinational regulations. Its low toxicity (LD₅₀>5000 mg/kg) and biodegradation characteristics meet the 12 principles of Green chemistry, especially in replacing traditional volatile amines (e.g., triethanolamine) in water-based coatings and daily chemical products. Industrial hygiene studies have shown that the allowable exposure limit (PEL) of Tris in the air in an 8-hour working environment is 10 mg/m³, which is much higher than the actual use of the concentration to ensure operator safety.
Technological innovations continue to strengthen the market position of Tris(Hydroxymethyl)Aminomethane. Ultra-pure products (purity >99.99%) developed through nano-purification technology can meet high-end needs such as semiconductor cleaning and gene sequencing; Functionalized derivatives, such as Tris-EDTA and TRIS-borate, have expanded their applications in DNA sequencing gels and fuel cell electrolytes. Enterprises can also provide customized services according to customer needs, such as premixed buffer, freeze-dried preparations, etc., to enhance the added value of products.
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