Tris(Hydroxymethyl)Aminomethane CAS 77-86-1
Tris(Hydroxymethyl)Aminomethane CAS 77-86-1 With Best Quality
- Appearance:Powder
- Purity:99.8%
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Name: Tris(Hydroxymethyl)Aminomethane
CAS: 77-86-1
MOQ: 1KG
Directory Guidance on Tris(Hydroxymethyl)Aminomethane
Chemical Structure
Basic Info:
| Melting point | 167-172 °C(lit.) |
| Boiling point | 219-220 °C10 mm Hg(lit.) |
| density | 1,353 g/cm3 |
| vapor pressure | 0.0267 hPa (20 °C) |
| refractive index | 1.4170 (estimate) |
| Fp | 219-220°C/10mm |
Product Introduction:
Tris(Hydroxymethyl)Aminomethane (Tris for short) is a white crystalline powder widely used in biochemistry and pharmaceutical chemistry. It has high water solubility and can be dissolved in solvents such as water, methanol and ethanol.
Tris(Hydroxymethyl)Aminomethane is often used as a buffer, and is also used in vulcanization accelerators, cosmetics (creams, lotions), mineral oils, paraffin emulsifiers, and biological buffers.
As an alkaline compound, the pKa value of Tris(Hydroxymethyl)Aminomethane is about 8.1, showing a certain alkalinity. It can form salts with acids, so it is widely used in experiments to adjust the pH of the solution to an appropriate range. Due to its strong buffering capacity, it is often used in the extraction and purification of biological fluids and biomolecules to maintain the stability of the experimental system.
Tris(Hydroxymethyl)Aminomethane is easy to decompose at high temperatures, especially under strong acid or high temperature conditions, and thermal decomposition reactions may occur. The decomposition products include harmful ammonia, so attention should be paid to temperature and environmental conditions when using it. Under normal circumstances, Tris has high stability in aqueous solution, but long-term storage may cause the solution to slowly degrade, affecting its buffering effect.
In addition, the application of Tris (Hydroxymethyl) Aminomethane is also widely involved in the research field of pharmaceutical preparations, especially in the study of protein stability. It plays a key role in maintaining protein structure and can prevent protein degradation or denaturation.
Nature and Specifications:
| Item | Specification |
| Product Name | Tris(Hydroxymethyl)Aminomethane |
| CAS No. | 77-86-1 |
| Appearance | Powder |
| Shelf Life | 2 years |
| Packing | As your requirements |
| storage temp. | 20-25°C |
| solubility | H2O: 4 M at 20 °C, clear, colorless |
| form | crystalline |
| color | white |
| PH | 10.5-12.0(4 m in water, 25 °C) |
| PH Range | 7 – 9 |
Product service:
- Certificate Of Analysis (COA)
- Material Safety Data Sheet (MSDS)
- Route of synthesis (ROS)
- Method of Aanlysis (MOA)
- Nuclear Magnetic Resonance (NMR)
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- Factory audit
1. Pharmaceutical intermediates
Tris (Hydroxymethyl) Aminomethane is widely used in drug synthesis as a pharmaceutical intermediate, especially in the synthesis of antibiotics. It is an important chemical intermediate in the synthesis process, participating in the construction of molecular structure or regulating reaction conditions. In some complex drug syntheses, its stability and buffering effect can ensure the constant reaction conditions, thereby improving the efficiency and yield of the synthesis.
2. Biological buffer
Tris (Hydroxymethyl) Aminomethane plays a very important role in biochemistry and molecular biology as a biological buffer. It can stabilize the pH of the solution within a certain pH range, thereby providing a stable environment for biological experiments such as enzyme reactions, nucleic acid extraction, and protein analysis.
Tris (Hydroxymethyl) Aminomethane is widely used in the preparation of buffers, such as Tris-HCl buffer, as an important component in cell culture fluids, enzyme reaction systems, and PCR amplification systems. Due to its stability in biological systems, Tris is a common basic reagent in biological research.
3. Reference substance for acid titration
Tris (Hydroxymethyl) Aminomethane can also be used as a reference substance in acid titration. Because it can react with acid and can exist stably within a certain pH range, it is used to prepare standard solutions. Especially in chemical analysis and quality control, as a standard substance in titration analysis, it can accurately determine the amount of acid in the solution and is widely used in chemical experiments, environmental testing and other fields.
4. Medical diagnosis and clinical application
In the field of medical diagnosis, Tris (Hydroxymethyl) Aminomethane is widely used in molecular diagnostic technology, especially in technologies related to DNA and RNA analysis. For example, in experiments such as gene detection, PCR amplification, and nucleic acid quantification, Tris is used as a component of the buffer to ensure the stability of the pH in the reaction system, thereby improving the accuracy and repeatability of the experiment.
Tris (Hydroxymethyl) Aminomethane is also commonly used in certain clinical tests, such as stabilization, storage and transportation of blood samples using Tris buffer. In some special blood biochemistry tests, Tris buffer is used as a calibration solution or as part of the reaction system to ensure that the sample and reagent react under appropriate environmental conditions.
5. Industrial Applications
In industrial applications, the main uses of Tris (Hydroxymethyl) Aminomethane include water treatment and the manufacture of cleaning agents. Due to its excellent buffering properties, it is often used to adjust the pH value in industrial water treatment processes to ensure the stability of the reaction process. In addition, it is also used to clean industrial equipment, especially in the biopharmaceutical and food processing industries, as one of the components for cleaning and removing pollutants.
6. Vulcanization Accelerator
In the rubber industry, Tris (Hydroxymethyl) Aminomethane, as one of the vulcanization accelerators, can promote the vulcanization reaction of rubber and improve the performance and stability of rubber. By accelerating the vulcanization process, it helps rubber form a stronger cross-linked structure, thereby improving the wear resistance, elasticity and aging resistance of rubber. Therefore, in the production of rubber products, it is used as an auxiliary additive to improve the quality of the final product.
7. Application in cosmetics
In the cosmetics industry, Tris (Hydroxymethyl) Aminomethane is widely used as a stabilizer and pH regulator in various skin care and cleaning products. For example, in the formulation of products such as creams, facial cleansers, and conditioners, it can help adjust and maintain the pH value of the product to prevent the product ingredients from becoming ineffective due to changes in pH. In addition, it also has a certain emulsifying effect, which can improve the texture and feel of the product.
8. Mineral oil and paraffin emulsifier
Tris (Hydroxymethyl) Aminomethane is also used as a mineral oil and paraffin emulsifier. In the petrochemical industry, Tris as an emulsifier can help stabilize the oil-water mixture and avoid oil-water separation, thus playing an important role in the production process of petroleum and chemical products. This property makes it widely used in the application of lubricants, solvents, and additives in the chemical industry.
9. Biological buffer
In addition to the above applications, Tris (Hydroxymethyl) Aminomethane as a biological buffer cannot be ignored in medical research, cell culture, and drug development. In molecular biology, cell biology and immunology research, it is one of the basic buffers for adjusting pH, and is often used in cell culture media, tissue sample preservation solutions, and buffer solutions in immunological experiments. It can ensure the stability of pH in the experimental system, thereby ensuring the reliability and repeatability of research results.
1. Strong buffering capacity
Tris has a strong buffering capacity within a certain pH range, especially within the pH range of 7 to 9, which makes it one of the most commonly used buffers in biochemical experiments. It can effectively maintain the pH value of the solution and maintain the stability of enzyme reactions, protein and nucleic acid analysis.
2. Strong water solubility
Tris has a high water solubility, which makes it easy to dissolve in water to form a stable solution. Its solubility makes it very easy to use as a buffer component in various experiments, especially in biochemistry and molecular biology, where Tris buffer is one of the commonly used basic reagents.
3. Non-toxicity and biocompatibility
Tris’ relatively low toxicity and good biocompatibility make it very suitable for biological experiments. It does not have a direct toxic effect on most biological molecules (such as proteins, DNA, RNA, etc.), so it is often used in biochemical reactions such as cell culture and enzymatic experiments.
4. Stability and high temperature resistance
Tris has high chemical stability and can maintain its buffering effect under conditions of large temperature changes. It is not easy to decompose and deteriorate. It can resist the influence of heat and acid to a certain extent, making it have the advantages of long-term storage and stable use in various biological experiments, especially in biological experiments with high temperature or heat treatment. It can provide reliable buffering effect.
5. Relatively cheap and easy to obtain
Compared with some other buffers, Tris is relatively cheap, with sufficient supply on the market, easy to buy and store, and is an economical choice for laboratories or production environments that need to use a large amount of buffer.
6. Easy to prepare and use
Tris has good solubility and stability and is very easy to use. In most experiments, you only need to simply dissolve Tris powder in water and adjust it to the required pH value. It is also very simple to prepare buffers of different concentrations without complicated operations.
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Related References:
chemicalbook-Tris(Hydroxymethyl)Aminomethane
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