O-Toluidine CAS 95-53-4
Factory wholesale O-Toluidine CAS 95-53-4
- Appearance:Liquid
- Purity:99.8%
- Delivery:30days
- Sample Available:Available
- Payment:L/C,T/T,D/P,Paypal,Money Gram,Western Union
- Incoterm: FOB,CFR,CIF,EXW,FCA,CPT,CIP
- Transporta:Ocean, Land,Air, DHL，TNT FedEx
Name: O-Toluidine
CAS: 95-53-4
MOQ: 1KG
Directory Guidance on O-Toluidine
Chemical Structure
Basic Info:
| Melting point | -23 °C |
| Boiling point | 199-200 °C(lit.) |
| density | 1.008 g/mL at 25 °C(lit.) |
| vapor density | 3.7 (vs air) |
| vapor pressure | 0.26 mm Hg ( 25 °C) |
| refractive index | n20/D 1.572(lit.) |
| Fp | 185 °F |
Product Introduction:
O-Toluidine (chemically known as 2-methylaniline) is an important organic intermediate with the molecular formula C7H9N and an important chemical structure featuring an ortho-methylation, where its methyl group (-CH3) on benzene rings alternates with amino groups (-NH2). This structure confers it unique chemical properties such as high reactivity and selectivity. From its physical properties standpoint, O-Toluidine presents as a colorless to light yellow oily liquid at room temperature with faint aromatic aroma; its boiling point at around 200degC; its relative density at 1.008; slightly soluble in water but easily solubed by organic solvents like ethanol or ether; melting point at -16degC; easy crystallization at lower temperatures.
O-Toluidine production on an industrial level primarily utilizes the nitrotoluene reduction method. Raw material o-nitrotoluene serves as the basis for this reduction reaction, with iron powder or hydrogen as catalysts, followed by purification steps such as neutralization, distillation and other means to obtain its finished product. This process places stringent requirements on controlling reaction conditions to ensure optimal conditions, in order to avoid excessive reduction or by-product formation. Recently, due to tightening environmental protection regulations, some companies have turned to catalytic hydrogenation technology in place of traditional iron powder reduction methods to decrease wastewater discharge and increase product purity.
O-Toluidine amino group can contribute to reactions such as diazotization and acylation, while the presence of methyl influences its site selectiveness for substitution reactions on benzene rings – for instance in dye synthesis where its ortho-para positioning effect allows specific positions to enter preferentially for dye production. Furthermore, O-Toluidine’s easy formation under acidic conditions expands its range of applications.
O-Toluidine must be handled carefully to protect both its safety and toxicological properties. Studies have shown that O-Toluidine can enter human bodies through skin contact, inhalation or ingestion and over long exposure may damage blood, liver and nervous systems as well as be listed by IARC as Class 2B carcinogen. Therefore, industrial production facilities must strictly implement closed operation, local ventilation measures and personal protection measures, while concentration in working environments should be closely monitored regularly.
Nature and Specifications:
| Item | Specification |
| Product Name | O-Toluidine |
| CAS No. | 95-53-4 |
| Appearance | Liquid |
| Shelf Life | 2 years |
| Packing | As your requirements |
| storage temp. | 2-8°C |
| solubility | 1.5 g/100 mL (25°C) |
| form | liquid |
| pka | 4.44(at 25℃) |
| Colour Index | 37077 |
Product service:
- Certificate Of Analysis (COA)
- Material Safety Data Sheet (MSDS)
- Route of synthesis (ROS)
- Method of Aanlysis (MOA)
- Nuclear Magnetic Resonance (NMR)
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- Free Sample
- Factory audit
O-Toluidine is an essential raw material in the dye and pigment industry for synthesising azo dyes, Coupled with beta-naphthol it produces red hues; reacting with resorcinol produces yellow pigments; its derivatives may also be used as intermediates for manufacturing vulcanized and oxidized dyes to meet light resistance requirements and wash resistance requirements of different materials.
O-Toluidine plays an essential role in pharmaceutical chemistry. It serves as an intermediate in the production of sulfonamides, antipyretic analgesics and antituberculosis drugs; for example acetylated forms can be produced using an acylation reaction which leads to antimicrobial compounds; additionally it’s often employed as an insecticide and herbicide ingredient due to the synergy between amino and methyl groups that improves selectivity against target organisms; more recently with developments around green pesticides more attention has been drawn towards molecular design of chiral pesticides containing O-Toluidine molecules;
O-Toluidine is widely utilized in the rubber and resin industries as a vulcanization accelerator and antioxidant precursor, helping improve wear- and aging-resistance in rubber products. When combined with sulfur or zinc oxide as additives, O-Toluidine accelerates crosslinking reactions of rubber to shorten vulcanization time while simultaneously improving mechanical properties of products. Furthermore, this compound can be modified epoxy resin curing agents by adding amino groups that increase bond strength to substrate.
O-Toluidine is commonly employed in analytical chemistry as a chromogenic reagent or indicator. For example, its reaction with nitrite yields a red complex used for quantitative detection of nitrite in water or food quality testing. Furthermore, in electrochemical analysis its polymerization product Poly O-Toluidine helps modify electrode surfaces so sensors can more readily recognize specific molecules due to its conductivity and environmental stability.
As new material technology develops, O-Toluidine continues to find greater applications in polymer materials. It can serve as a monomer that contributes to copolymerization processes that produce engineering plastics with improved temperature resistance and corrosion resistance; its rigid benzene ring structure aids molecular assembly during liquid crystal synthesis processes for optimized photoelectric response properties of such materials.
From the perspective of chemical properties, O-Toluidine has both reactivity and stability, and can maintain high conversion rates in a variety of reaction systems. The strong nucleophilicity of its amino group makes it easy to react with reagents such as acyl chlorides and anhydrides, while the conjugated structure of the benzene ring gives the product good thermal stability. For example, in the diazotization reaction, the diazonium salt of O-Toluidine is not easy to decompose and can be stored for a long time for subsequent coupling. This feature significantly improves its applicability in continuous production.
The maturity of the synthesis process is another core advantage of O-Toluidine. After decades of industrial practice, its production process has formed a complete technical system from raw material pretreatment, catalytic reduction to distillation and purification. Modern processes can increase the purity of the product to more than 99.5% by optimizing the catalyst carrier and controlling the hydrogenation pressure and temperature, while reducing energy consumption by about 30%.
The wide range of application scenarios further highlights the market value of O-Toluidine. As a multi-field cross-cutting chemical, its demand is less affected by the cyclical fluctuations of downstream industries. For example, environmental protection upgrades in the dye industry have driven the demand for high-purity O-Toluidine, while innovative drug research and development in the pharmaceutical industry has spawned a market space for customized derivatives. This diversified application structure enhances the risk resistance of the industrial chain.
In terms of safety and environmental protection, the standardized management system of O-Toluidine is becoming more and more perfect. By adopting closed production equipment and establishing wastewater and waste gas recovery devices, enterprises can reduce the discharge of three wastes to below the national standard. Some advanced factories have also introduced biodegradation technology to treat wastewater containing the product, decomposing it into harmless substances through microbial metabolism, thereby reducing environmental load.
In terms of economy, O-Toluidine has low raw material costs and stable supply. As the main raw material, the production technology of o-nitrotoluene is highly compatible with the toluene nitration process, and can be supplied on a large scale based on the existing petrochemical infrastructure. In addition, O-Toluidine has significant high added value. After deep processing, 1 ton of raw materials can produce dyes or pharmaceutical intermediates with several times the value, and the return on investment is very attractive.
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Related References:
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O-Toluidine Manufacturer
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Transport proposal
1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).
2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).
3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).
4. For high-value products, please choose air or express to ensure the safety of product transportation.
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We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.
Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
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