2-Bromochlorobenzene CAS 694-80-4


High Quality 2-Bromochlorobenzene CAS 694-80-4
- Appearance:Liquid
- Purity:99.8%
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Name: 2-Bromochlorobenzene
CAS: 694-80-4
MOQ: 1KG
Directory Guidance on 2-Bromochlorobenzene
Chemical Structure
Basic Info:
Melting point | -13–11°C |
Boiling point | 204 °C(lit.) |
density | 1.638 g/mL at 25 °C(lit.) |
refractive index | n20/D 1.582(lit.) |
Fp | 196 °F |
storage temp. | Sealed in dry,Room Temperature |
solubility | 0.045g/l |
Product Introduction:
2-Bromochlorobenzene, commonly referred to as o-bromochlorobenzene, is an important organic compound with numerous applications and special chemical properties. As its scientific formula C6H4BrCl indicates, this colorless liquid boasts unique chemical properties and uses. With a molecular weight of 191.45, its density at 25 deg C stands at approximately 1.638 g/mL while melting point occurs between -13degC and -11degC and its boiling point stands at 204degC.
2-Bromochlorobenzene can be produced using the diazotization reaction of o-chloroaniline, with specific procedures involving mixing it with hydrobromic acid at room temperature, cooling it to 0degC, then stirring an aqueous sodium nitrite solution into it to form diazonium salt. Finally, cuprous bromide and hydrobromic acid can be used through Sandmeyer reaction to decompose diazonium salt into 2-Bromochlorobenzene for production – making this method suitable for organic chemistry because it effectively introduces two halogen atoms into organic molecules simultaneously. This synthetic method can efficiently introduce two halogen atoms; bromine and chlorine; making this method widely utilized across organic disciplines and fields alike.
2-Bromochlorobenzene serves a key function as an organic synthesis intermediate. Due to the presence of two halogen atoms – bromine and chlorine – in its molecular structure, 2-Bromochlorobenzene shows excellent reactivity across many organic reactions, making it useful in synthesizing complex organic compounds used as raw material in pharmaceutical, pesticide and dye industries. Furthermore, due to its strong toxicity safety regulations must be strictly observed when handling this solvent.
Safety-wise, 2-Bromochlorobenzene poses certain toxicity concerns and is harmful to eyes, respiratory system and skin. Therefore, inhalation or oral ingestion of this compound could pose risks for human health; to safeguard yourself during storage and use, place in sealed container in cool, dry area away from oxidants; additionally operators should wear appropriate protection such as gloves and protective glasses to reduce contact or inhalation of its vapors.
Nature and Specifications:
Item | Specification |
Product Name | 2-Bromochlorobenzene |
CAS No. | 694-80-4 |
Appearance | Liquid |
Shelf Life | 2 years |
Packing | As your requirements |
form | Liquid |
color | Clear colorless to yellow-orange |
Specific Gravity | 1.649 |
Water Solubility | 0.045 G/L (25 ºC) |
BRN | 1855303 |
Product service:
- Certificate Of Analysis (COA)
- Material Safety Data Sheet (MSDS)
- Route of synthesis (ROS)
- Method of Aanlysis (MOA)
- Nuclear Magnetic Resonance (NMR)
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2-Bromochlorobenzene is an indispensable organic chemical intermediate. Comprised of two halogen atoms – bromine and chlorine – its high chemical reactivity makes it widely applicable across numerous fields, from medicine and pesticides to dyes, organic synthesis and solvents; making this compound one of the fundamental raw materials in modern chemical production.
2-Bromochlorobenzene (BCHB) is an essential intermediate in the pharmaceutical synthesis of many medications. It can be used to synthesize antibiotics, antiviral drugs and new drug molecules for treating anticancer disease or cardiovascular diseases. 2-BCHB’s importance lies in its ability to introduce multiple functional groups through chemical reactions to produce complex drug structures; providing a key foundation for new drug discovery and development.
2-Bromochlorobenzene plays an integral part in pesticide chemistry, often acting as an intermediate in the production of insecticidal, herbicidal and bactericidal pesticides. Chemical reactions transform 2-Bromochlorobenzene into compounds with specific biological activities to protect crops against pests and weeds as efficiently as possible for agricultural production.
2-Bromochlorobenzene is widely employed within the dye industry. As either an initial starting material or intermediate for dye synthesis, 2-Bromochlorobenzene allows dye manufacturers to develop products with specific colors and properties for textile dyeing, leather tanning and other uses, providing critical support to its growth and expansion. It has found widespread application throughout textile, leather tanning and other material industries for coloring textiles, leathers and other materials – providing essential assistance in supporting growth of this market sector.
2-Bromochlorobenzene stands out in organic synthesis for its use as an extremely versatile compound with two halogen atoms – bromine and chlorine – present. Due to these properties, 2-Bromochlorobenzene can participate in numerous organic reactions including nucleophilic substitution reactions and coupling reactions which in turn convert 2-Bromochlorobenzene into other complex organic compounds like benzoic acid derivatives or aliphatic amines; making it widely utilized across fields including fine chemicals and materials science.
Two-Bromochlorobenzene can also be utilized as a solvent or extractant. Due to its insolubilitiy in water but solubility in organic solvents such as alcohol and ether, 2-Bromochlorobenzene is well-suited to serve this function, helping reactants mix more readily during organic reactions while at the same time being an extractant that separates and purifies certain organic compounds.
2-Bromochlorobenzene can be harmful and irritating to eyes, respiratory system and skin. Therefore, when stored and used it should be placed in an airtight container and kept away from sources of oxidants; operators should wear appropriate protection such as gloves or protective glasses in order to ensure operational safety and environmental sustainability.
As an important organic synthesis intermediate, 2-Bromochlorobenzene has many significant advantages, which makes it attract much attention in the chemical industry. Its molecule contains two halogen atoms, bromine and chlorine. This unique structure gives it high chemical reactivity. The presence of bromine and chlorine atoms provides abundant reaction sites for subsequent chemical transformations, enabling it to participate in various reaction types such as nucleophilic substitution and coupling reactions, thereby synthesizing complex organic compounds. This high reactivity makes 2-Bromochlorobenzene an ideal intermediate in organic synthesis, providing great convenience for chemists.
In addition to its high reactivity, 2-Bromochlorobenzene has a wide range of applications in many fields. In the field of medicine, it is an important intermediate for the synthesis of antibiotics, antiviral drugs, anticancer drugs, etc. By introducing multiple functional groups through chemical reactions, compounds with specific biological activities can be synthesized. In the field of pesticides, it can be used to synthesize highly efficient and low-toxic insecticides, herbicides and fungicides. In addition, in the dye industry, it is also a key raw material for the synthesis of a variety of dyes, and is widely used in the dyeing of textiles, leather and other materials. These diverse applications fully demonstrate its practical value.
From the perspective of physical properties, 2-Bromochlorobenzene is a colorless liquid with a high boiling point (204°C) and density (1.6378 g/mL). It is insoluble in water but soluble in organic solvents such as benzene and ether. These characteristics make it exhibit good stability and operability in organic synthesis. It can remain stable under a variety of reaction conditions and is easy to mix with other organic solvents to improve reaction efficiency. This stability is very important for chemical production and can ensure the smooth progress of the reaction process.
In terms of cost, 2-Bromochlorobenzene also has obvious advantages. Its synthesis method is relatively mature. It is usually prepared by the diazotization reaction of o-chloroaniline, with a simple process and low cost. In addition, the reaction selectivity in its synthesis process is high, and the product yield and purity are high, which makes it significantly cost-effective in large-scale industrial production. The efficient synthesis route and stable chemical properties enable it to achieve higher economic benefits in chemical production, which is very attractive to enterprises.
It is worth mentioning that 2-Bromochlorobenzene has multiple isomers, such as m-bromochlorobenzene and p-bromochlorobenzene. These isomers have their own characteristics in chemical properties and applications. For example, p-bromochlorobenzene shows higher reactivity in certain reactions, while m-bromochlorobenzene has unique advantages in specific synthetic pathways. This diversity provides more options for organic synthesis, and the appropriate isomer can be selected according to different application requirements, further expanding its application range.
In addition to being a synthetic intermediate, 2-Bromochlorobenzene can also be used as a solvent or extractant. Its characteristics of being insoluble in water but soluble in organic solvents enable it to be used as a solvent in certain organic reactions to help reactants mix and react better. In addition, it can also be used in the extraction process to separate and purify certain organic compounds. This characteristic further expands its application range in the chemical industry and gives it greater flexibility in industrial production.
Although 2-Bromochlorobenzene has certain toxicity, its physical and chemical properties are stable and not easy to decompose. During storage and use, as long as safety regulations are strictly followed and appropriate protective measures are taken, its potential harm to the environment and human health can be effectively controlled. This controllability makes it highly safe in industrial applications and also makes companies more assured when using it.
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Related References:
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